Gleevec for anal melanoma

Metrics details. Imatinib mesylate can induce rapid tumor regression, increase tumor antigen presentation, and inhibit tumor immunosuppressive mechanisms. We hypothesized that imatinib combined with ipilimumab would be tolerable and may synergize in patients with advanced cancer. Secondary objectives included evaluation of antitumor activity of the combination based on KIT mutation status and the capacity of tumor-associated immune biomarkers to predict response.

Melanoma results from malignant transformation of normal melanocytes and can therefore develop in any organ in which melanocytes are present. Since the vast majority of melanocytes are distributed throughout the epidermal layer of the skin, most malignant melanomas arise from the skin. However, a small subset of melanomas originate from noncutaneous tissues and organs, such as the mucosal surface of the oral cavity; nasal sinus; vagina, urethra and rectum; choroid and even visceral organs. The reasons for such differences in the prevalence of distinct histologic subtypes of melanoma among various populations are not well understood. Because of the overall low prevalence of mucosal and subungual melanomas in the general population, research on their biology and on systemic treatment has been substantially more limited than research on typical cutaneous melanomas. For patients with mucosal melanoma, prognosis is poor, and the median survival is short. Mucosal melanoma is generally considered an aggressive disease.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Mutations in KIT are more frequent in specific melanoma subtypes, and response to KIT inhibition is likely to depend on the identified mutation.

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